Cluster Headache Syndrome – Pipeline Review, 2019

Cluster headache syndrome refers to the headaches which often occur in cluster periods or in a cyclical pattern and is considered to be one of the most painful types of headaches. A cluster headache often occurs in the middle of the night with intense pain in or around one eye on one side of the head. These bouts of frequent attacks are also referred to as cluster periods and can often range in longevity from weeks to months. These bouts are followed by periods of remission when the headaches stop and these remission periods can last for months or years.

The common signs and symptoms can be excruciating pain in the affected eye or the region around the affected eye, one-sided pain, restlessness, excessive pain, redness of the eye on the affected eye, stuffy or the runny nose on the affected side, forehead or facial sweating on the affected side and pale skin or flushing of the face. The exact cause of cluster headache syndrome is unidentified, but the patterns of cluster headaches suggest that the abnormalities in the hypothalamus play an important role. There is no cure for the cluster headache syndrome but various treatment and management options exist such as oxygen therapy and medications such as triptans (sumatriptan), octreotide (sandostatin), local anesthetics and dihydroergotamine.

Pharmaceutical companies along with various research institutes have been focusing on studying and developing new treatment options for cluster headache syndrome. For instance; civamide nasal solution 0.01%, which is being studied by Winston Pharmaceuticals, Inc., is currently in phase-3 clinical trials for the civamide nasal solution for cluster headache (ECH).

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At present, more than 60% of the pipeline candidates for cluster headache syndrome are in the phase-3 stage. Majority of the studies are sponsored by industry.

Report Description

The report on ‘Cluster Headache Syndrome – Pipeline Review, 2019’ provides a comprehensive overview of the drugs that are in the R&D pipeline by indication or molecule for Cluster Headache Syndrome. The report provides a thorough analysis of the distribution of the pipeline products by clinical trial stage, indication, company, therapy area and details such as clinical trial stage, sponsor, description on every product in the pipeline. Products in the preclinical and clinical stage along with dormant & discontinued pipeline candidates are included in the report. The report also covers additional insights such as epidemiology overview and current market scenario for Cluster Headache Syndrome.

The report on ‘Cluster Headache Syndrome – Pipeline Review, 2019’, which is built by following a robust research methodology involving primary interviews and desk research, provides a complete overview of the R&D activity and pipeline products to assist companies in developing growth strategies and identifying emerging players.

Report Scope

• Thorough assessment of the pipeline products by areas such as development stage; route of administration; drug class; indication; sponsor; molecule type and drug target


• Comprehensive profiles of the pipeline products with details such as company overview; product description; R&D status; development activities; mechanism of action; molecule type; development stage; indications; funding and route of administration


• Overview of dormant and discontinued pipeline products


• Key insights in relation to the epidemiology of conditions being treated by the pipeline products and overview of the addressable or current market for the pipeline products


• Overview of the latest developments; news articles, press releases and relevant conferences

Report Methodology 

• All pipeline reports are built through the analysis of data primarily collected through credible desk research sources. Secondary research is supplemented by interviews conducted with key opinion leaders.


• Desk research sources includes global and regional clinical trials databases; annual reports, websites, press releases & investor presentations of companies; white papers; news articles; reports published by industry associations; articles/reports published on databases such as NCBI, ResearchGate; internal databases

Reasons to Buy this Report

• Develop effective growth strategies based on comprehensive overview of the R&D activity and pipeline products for Cluster Headache Syndrome


• Identify emerging players or competition in the market based on pipeline products and develop strategies to counter the emergence of these players


• Identify the focus of leading players in relation to R&D for Cluster Headache Syndrome


• Identify potential companies from a partnership or acquisition point of view based on current synergy in R&D activities or strategies to diversify R&D focus to drive growth in business


• Analyse the reasons behind dormant and discontinued products to make changes in the R&D focus if necessary